Physical servers for SAP tend to scale up, you will have to revisit how you architect this on virtual environment the recommendation are slightly different. Here are some best practises for SAP on VMware
- SAP Virtualization and VMware: Run SAP Virtual | United States
- SAP and VMware Virtualization Resources | United States
- SAP HANA Guidelines for running virtualized | SAP HANA
vSphere can handle these monster VM, but what you have consider is your availability requirements,things like vmotion will take a long time if sufficient bandwidth is not available and so on.